Unless you’re an advanced and competing bodybuilder you probably train through your body twice a week or more; or at least you should.
When doing full body- or half body workouts, one important thing to take into consideration is unloading your spine. If you do barbell squats or deadlifts in your first workout, doing dumbbell split squats or step-ups in the second workout will make a huge difference in your recovery (since the load on the back is reduced by 50 percent). Also, since most of life’s activities occur unilateral (single limb), most people in general need to focus more on unilateral movements instead of bilateral (both legs) for their lower body workouts.